Sterol regulatory element binding proteins (SREBPs) are endoplasmic reticulum (ER) residing transcription factors best known for their roles in regulation of genes mostly involved in the lipid biogenesis and metabolism in the liver and adipose tissues. This family of lipid transcription factors consists of SREBP1a, SREBP1c, and SREBP2. Sterol regulatory element binding proteins (SREBPs) are endoplasmic reticulum (ER) residing transcription factors best known for their roles in regulation of genes mostly involved in the lipid biogenesis and metabolism in the liver and adipose tissues. This family of lipid transcription factors consists of SREBP1a, SREBP1c, and SREBP2 .Activation of SREBPs require cleavage of the inactive ER membrane integral precursor protein (immature form) by two dedicated proteases in the Golgi apparatus, leading to the release and nuclear translocation of the soluble mature N-terminal SREBP (nt-SREBP) for transcriptional activity. SREBP-1 regulates genes mainly involved in fatty acid biogenesis as well as cholesterol biosynthesis, whereas SREBP-2 is a major regulator of cholesterol biogenesis. SREBP-1 activation has recently been linked to glucolipotoxic cell death in pancreatic beta cells and activation of SREBP-1 has also been found in response to anaerobic hypoxic ER stress and oxidative stress  Relevant articles fall in the scope of Journal of Diagnostic Techniques and Biomedical Analysis.

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