Chromatography is relied on by many disciplines as a method of separating the components of a mixture. The basic idea of the process is that distinct compounds have different levels of solubility, causing them to travel through the stationary phase at different speeds, resulting in their separation as more highly soluble compounds separate faster than those with lower solubilities. The method has been used since the beginning of the 20th century when it was developed by Russian botanist Mikhail Semyonovich Tsvet. Since then, it has been adopted by a wide range of industries, with the list of applications of chromatography continuing to grow and evolve. Continuing advancements in the methodology and technology used for chromatography has helped to establish the process as a standard laboratory technique across sectors, allowing it to remain relevant and useful, meeting analytical demands in a range of scientific scenarios.

Below, we discuss the recent developments in chromatography that is helping to continue to move the method forward.

Pharmaceutical analysis

The pharmaceutical industry is heavily regulated due to the necessity of ensuring the safety and efficacy of its products. The sector has relied on chromatography for decades to reliably measure the levels of impurities and degradation products within active pharmaceutical ingredients (APIs) to determine their safety and meet the specific guidelines implemented by authorities worldwide. All areas in the pharmaceutical industry, from research through to drug development and quality control use chromatography to assess the chemical purity of the products being developed. Currently, the gold standard of pharmaceutical analysis is reversed-phase liquid chromatography (RPLC). However, as costs of drug development have risen, and the complexity of the drug discovery process has increased in recent years, the pharmaceutical industry has demanded better performance from RPLC methods, both in terms of throughput and resolution.

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Journal of Diagnostic Techniques and Biomedical Analysis
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