In mass spectrometry, matrix-assisted laser desorption/ionization (MALDI) is an ionization technique that uses a laser energy absorbing matrix to create ions from large molecules with minimal fragmentation. 

 It has been applied to the analysis of biomolecules (biopolymers such as DNA, proteins, peptides and sugars)

MALDI methodology is a three-step process. First, the sample is mixed with a suitable matrix material and applied to a metal plate. Second, a pulsed laser irradiates the sample, triggering ablation and desorption of the sample and matrix material. Finally, the analyte molecules are ionized by being protonated or deprotonated in the hot plume of ablated gases, and then they can be accelerated into whichever mass spectrometer is used to analyse them.

The type of a mass spectrometer most widely used with MALDI is the TOF. Now a days analysis of protein structure is the most important technique in research related to proteins. Journal of Biochemistry deals with such topics and is inviting researchers to publish with the journal for 2020 issue.

Sandra,

Editorial assistant,

Journal of Biochemistry and Physiology.

Email: biochemistry@molecularbiol.com