Immunosuppressive drugs, also known as immunosuppressive agents, immunosuppressants and antirejection medications are drugs that inhibit or prevent activity of the immune system.They are also administered as posttransplantory immunosuppressants to prevent the acute transplant rejection and graft-versus-host disease. Immunosuppressive drugs are given in two phases; an initial induction phase involving a high dose, and a later maintenance phase which involves using the drug in the long term at a lower dose. All current immunosuppressive drugs come with limitations. One of the major limitations of these drugs is immunodeficiency. A fine balance needs to be reached between suppressing immune function sufficiently to avoid rejection, preventing drug toxicity, and maintaining enough immune function to fight off disease. The Archives of Transplantation Journal is here to have the write ups of your continued research carried out to find ways to alleviate the risk of rejection, improve diagnosis and maintain long term survival of the transplant; all of which would have a significant impact on the strained organ supply. With Regards, Managing Editor Archives of Transplantation Journal