Precise and critical analysis of biomedical data is crucial in our understanding of the pathological metabolism and necessary elements in the progress of a new drug development. Therefore this new open access journal (Journal of Pharmacological & Biomedical Analysis) is an important and welcome initiative for a new communication platform of research community allowing the rapid exchange of the scientific data. Precise and critical analysis of biomedical data is crucial in our understanding of the pathological metabolism and necessary elements in the progress of a new drug development. Therefore this new open access journal (Journal of Pharmacological & Biomedical Analysis) is an important and welcome initiative for a new communication platform of research community allowing the rapid exchange of the scientific data. An evolution of our understanding of tumor energy metabolism is a good example how our knowledge is under the constant changes. It was Otto Warburg who in 1956 discovered that for the cancer cells, glycolysis, non-oxidative degradation of glucose is the main source of energy (ATP). Glucose is the only source of the basic building block for the growing cells eg. ribose source. It seems that hyperglycemia, up normal blood glucose concentration, as seen in diabetic patients, should be a serious risk factor for the cancer diseases. In fact several recent studies prove such conclusion. On the cellular level it was reported that hyperglycemia has devastating influence on the cells and induce oxidative stress and ROS (reactive oxygen species) production. Hyperglycemia decrease mitochondrial function and suppress oxidative phosphorylation pushing the cell energy metabolism towards glycolysis (Crabtree effect), and increase mutagenesis also. Glucose modulate the mitochondrial adaptation in tumor cells caused an increase in IF1 (inhibitor factor of ATP synthase) expression level. Even transient hyperglycemia causes persistent epigenetic changes and altered gene expression for at least 6 days. Hyperglycemia stabilized hypoxia-inducible factor-1 alpha, crucial for the expression of enzymes from glycolytic pathway. Relevant articles fall in the scope of Journal of Diagnostic Techniques and Biomedical Analysis.

Regards

Katherine Gray

Editorial Coordinator

Journal of Diagnostic Techniques and Biomedical Analysis