History Of Synthetic Biology

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In the 1970s scientists began to conduct experiments with genetic engineering and recombinant DNA technology, in which they modified the genetic code of wild-type (naturally occurring) bacteria by inserting single wild-type genes that could alter bacterial function. This technology led to the production of biologic drugs, agents made from proteins and other organic compounds produced by bacteria with recombinant DNA; one such compound is synthetic insulin. However, because genetic engineering uses existing genes and bacteria, it has technical limitations and is expensive.

Synthetic biology, field of research in which the main objective is to create fully operational biological systems from the smallest constituent parts possible, including DNAproteins, and other organic molecules. Synthetic biology incorporates many different scientific techniques and approaches. The synthetic systems created may be used to generate products ranging from ethanol and drugs to complete synthetic organisms such as complex bacteria that can digest and neutralize toxic chemicals. Ideally, these customized synthetic biological systems and organisms would be much safer and less complicated than approaches based on the manipulation of naturally occurring biological entities. Synthetic systems and organisms would essentially operate like biological “factories” or “computers.”

 

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