The Journal focuses on calprotectin, Crohn’s disease, ulcerative colitis, inflammatory bowel disease. Calprotectin is a protein released by a type of white blood cell called a neutrophil. When there is inflammation in the gastrointestinal tract, neutrophils move to the area and release calprotectin, resulting in an increased level in the stool. Inflammatory bowel disease (IBD) involves chronic inflammation of your digestive tract. Crohn's disease is an IBD. It causes inflammation of your digestive tract, which can lead to abdominal pain, severe diarrhea, fatigue, weight loss and malnutrition. Inflammation caused by Crohn's disease can involve different areas of the digestive tract in different people. Ulcerative colitis is an IBD that causes long-lasting inflammation and ulcers (sores) in your digestive tract. Ulcerative colitis affects the innermost lining of your large intestine (colon) and rectum.

Fecal calprotectin is a marker of inflammation in inflammatory bowel disease (IBD). Since mucosal healing has become a goal of treatment in IBD we examined how reliably calprotectin levels reflect mucosal disease activity. Fecal calprotectin levels correlate significantly with endoscopic disease activity in IBD. The test appears useful in clinical practice for assessment of endoscopic activity and remission.

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Research and Reports in Gastroentrology
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