The Journal focuses on Neuroendocrine tumors, EMT, Snail1, Snail2, Foxc2, E-cadherin, b-catenin. To elucidate the role of epithelial-mesenchymal transition markers in gastroenteropancreatic neuroendocrine tumors (GEP NETs) and the potential usefulness in their clinical management. One hundred ten GEP NET paraffinembedded samples were immunohistochemically analyzed for E-cadherin, N-cadherin, b-catenin, vimentin, Snail1, Snail2, Twist, and Foxc2 protein expression. The 5-year survival rate was reduced for those patients showing high Snail1 protein levels, a cytoplasmic E-cadherin pattern, reduced N-cadherin expression, and loss of E-cadherin/b-catenin adhesion complex integrity at the cell membrane. Interestingly, high b-catenin expression was useful in identifying a grade 1 NET subgroup with a favorable clinical course. Importantly, it also helped to discriminate small-cell vs large-cell grade 3 neuroendocrine carcinomas. B-Catenin and N-cadherin immunohistochemical detection might be a useful tool in the differential diagnosis of small-cell vs large-cell G3 neuroendocrine carcinomas. High Snail1 and Foxc2 expression is associated with the invasion and metastatic spread of GEP NETs.

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