In a new study, researchers found that personal perception can be an important indicator for the early detection of Alzheimer’s disease,that individuals with subjectively felt memory problems also exhibited on average measurable cognitive deficits that were associated with abnormalities in the spinal fluid.Early diagnosis and therapy development could benefit from these findings.The research was conducted by led by the German Center for Neurodegenerative Diseases. When memory deteriorates according to one’s own perception, but mental performance—following objective criteria—is still within the normal range, this is referred to as ‘subjective cognitive decline’ (SCD).

People with SCD have an increased risk of developing dementia in the long term. However, little is known about the mechanisms underlying subjective memory problems.A total of 449 women and men—their average age was about 70 years—participated in the study.These people had consulted the clinics for diagnostic clarification of persistent subjective cognitive complaints, usually after a doctor’s referral.However, in the usual tests, they were assessed as cognitively normal. It was thus determined that they had SCD.The other 209 study participants were classified as cognitively healthy based on interviews and the same cognitive testing.

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Peter K
Editorial Assistant
Journal of Neuroscience and Clinical Research